Beta-amyloid imaging agents, methods of manufacture, and methods of use thereof

A compound having Formula 1 or a pharmaceutically acceptable salt thereof.

• wherein
• X is CH or N;
• Y is CH or N;
• wherein X and Y are not the same;
• R1 is H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C7-C13 arylalkylene, carbamoyl C1-C6 alkyl, or Y and R1 are joined to form a C2-C4 alkylene, C2-C4 alkenylene, or thio-C1-C3 alkylene linkage between Y and the amine nitrogen to which R1 is attached;
• and
• R2 is H, OH, halo, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, or C6-C12 aryl.