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US 2014/0348745 A1Published application
Chimeric therapeutic anti - cd37 antibodie hh1
AssigneeNordic Nanovector AS
InventorsRoy H. Larsen, Jostein Dahle
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Abstract
The present invention relates to chimieric or humanized antibodies derived from the mouse monoclonal antibody HH1. The applications of the present invention include therapeutic applications in which pharmaceutical compositions comprising the antibodies of the present invention or radioimmunoconjugates hereof are used for treating B-cell malignancies.
Claims17
An antibody that binds to human CD37 and that is derived from:
- a) a murine monoclonal antibody that is defined by:
- i) a variable heavy chain comprising the amino acid sequence shown in SEQ ID NO:
- 1;
- and
- ii) a variable light chain comprising the amino acid sequence shown in SEQ ID NO:3, or from
- b) a non-human antibody recognizing the same epitope of human CD37 as the antibody defined in a) or recognizing an epitope that overlaps with said epitope;
- wherein said antibody is a chimeric or a humanized antibody.
4 more elements
2-20. (canceled)
A method of pretreatment for a B-cell malignancy comprising:
- blocking CD37 in normal tissues of a subject;
- and
- providing said subject an injectable preparation comprising a chimeric or humanized HH1 antibody that is conjugated with a radionuclide or toxin.
Dependencies are inferred from the claim text.