Avian Derived Antibodies
AssigneeSynageva BioPharma Corp.
InventorAlex J. Harvey
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Abstract
The invention is drawn to a composition comprising an isolated mixture of cytotoxic anti-CD20 antibody molecules produces in a transgenic avian. The antibody molecules have a heavy chain and a light chain and exhibit an increased level of antibody-dependent cell-mediated cytotoxicity (ADCC) as compared to that of anti-CD20 antibody molecules produced by CHO cells.
Claims6
A composition comprising an isolated mixture of cytotoxic anti-CD20 antibody molecules produced in a transgenic avian, wherein the antibody molecules comprise a heavy chain and a light chain whose amino acid sequences set forth from position 23 to position 235 of SEQ ID NO:1 and from position 20 to position 470 of SEQ ID NO:
- 2, respectively, wherein the isolated mixture of cytotoxic anti-CD20 antibody molecules exhibit an increased level of antibody-dependent cell-mediated cytotoxicity (ADCC) as compared to that of anti-CD20 antibody molecules produced in CHO cells and having the same amino acid sequence.
Dependencies are inferred from the claim text.