Drug delivery product and methods
AssigneeUniversity of Massachusetts
InventorGary R. OSTROFF
Life of this patent
Estimating the term…
Abstract
The present invention provides a particulate delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload molecule and a payload trapping molecule. The invention further provides methods of making and methods of using the particulate delivery system.
Claims30
A particulate delivery system comprising an extracted yeast cell wall comprising beta-glucan and a payload trapping molecule.
-7. (canceled)
-19. (canceled)
(canceled)
The particulate delivery system of claim 19 wherein the polynucleotide comprises a nucleotide sequence that restores the function of an absent, defective or inhibited gene.
31-33. (canceled)
A method of delivering a payload molecule to a cell comprising the steps of:
- providing an extracted yeast cell wall comprising beta-glucan, the yeast cell wall defining an internal space;
- contacting the extracted yeast cell wall with a payload molecule wherein the payload molecule becomes at least partially enclosed within the internal space;
- contacting the extracted yeast cell wall with a payload trapping molecule wherein the payload trapping molecule at least partially confines the payload molecule within the extracted yeast cell wall to form a particulate delivery system, wherein the payload molecule and the payload trapping molecule are soluble in the same solvent system;
- and
- contacting a cell with the particulate delivery system.
-74. (canceled)
A method of making a particulate delivery system comprising the steps of:
- providing an extracted yeast cell wall comprising beta-glucan, the yeast cell wall defining an internal space;
- contacting the extracted yeast cell wall with a payload molecule wherein the payload molecule becomes associated with extracted yeast cell wall;
- and
- contacting the extracted yeast cell wall with a payload trapping molecule wherein the payload trapping molecule stabilizes the association of the payload molecule and the extracted yeast cell wall to form a particulate delivery system.
-89. (canceled)
-104. (canceled)
(canceled)
Dependencies are inferred from the claim text.