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AssigneeAdvanced Bionutrition Corporation
InventorArun K. Dhar
Estimating the term…
The present invention provides bivalent oral vaccines against infectious pancreatic necrosis virus (IPNV) and infectious salmon anemia virus (ISAV). Yeast cells comprise an expression vector comprising (i) a polynucleotide sequence encoding a VP2 capsid protein of IPNV and (ii) a polynucleotide sequence encoding one or more antigenic epitopes of hemaglutinin of ISAV. The yeast cells express sub-viral particles (SVP) comprising a VP2 capsid protein of IPNV and one or more antigenic epitopes of hemaglutinin of ISAV. The yeast cells and SVP may be administered in an effective amount to increase the amount of antibodies against IPNV and ISAV in the fish, preferably Salmonidae. The yeast cells and SVP may be in the form of fish food for administering to the fish orally.
Yeast cells comprising an expression vector comprising (i) a polynucleotide sequence encoding a VP2 capsid protein of infectious pancreatic necrosis virus (IPNV) and (ii) a polynucleotide sequence encoding one or more epitopes of hemaglutinin of infectious salmon anemia virus (ISAV).
Sub-viral particles (SVP) comprising a VP2 capsid protein of IPNV and one or more epitopes of hemaglutinin of ISAV.
A method for vaccinating fish against IPNV and ISAV comprising administering yeast cells to the fish, wherein the yeast cells comprise an expression vector comprising (i) a polynucleotide sequence encoding a VP2 capsid protein of infectious pancreatic necrosis virus (IPNV) and (ii) a polynucleotide sequence encoding one or more epitopes of hemagglutinin of infectious salmon anemia virus (ISAV).
A method for vaccinating fish against IPNV and ISAV comprising administering sub-viral particles to the fish, wherein the sub-viral particles comprise a VP2 capsid protein of IPNV and one or more epitopes of hemaglutinin of ISAV.
A method of making sub-viral particles (SVP) comprising a VP2 capsid protein of IPNV and one or more epitopes of hemaglutinin of ISAV comprising transforming yeast cells with an expression vector comprising (i) a polynucleotide sequence encoding a VP2 capsid protein of IPNV and (ii) a polynucleotide sequence encoding one or more epitopes of hemaglutinin of ISAV.
Dependencies are inferred from the claim text.