Novel semi-synthetic small molecules for the treatment parasitic disease
AssigneeThe Regents of the University of California
InventorsKhanitha Pudhom, Gabriel Navarro, James McKerrow, Roger Linington
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Abstract
Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping Sickness.
Claims20
A novel semi-synthetic derivatized compound of Merulin A, or a salt or derivative thereof, wherein the compound has the following structure, wherein R may be any subsitiuent:
A method for producing a novel semi-synthetic derivatized compound of Merulin A for the treatment of African sleeping sickness, the method comprising a one step derivatization of Merulin A from the microbial fermentation broth.
A method for treating a disease, the method comprising administering to a subject suffering from a disease a novel semi-synthetic derivatized compound of Merulin A, wherein the disease is selected from the group consisting of:
- Amoebiasis, Ascariasis, Babesiosis, Chagas disease, Clonorchiasis, Cryptosporidiosis, Diphyllobothriasis, Dracunculiasis (caused by the Guinea worm), Echinococcosis, Elephantiasis, Enterobiasis, Fascioliasis, Fasciolopsiasis, Filariasis, Giardiasis, Gnathostomiasis, Hymenolepiasis, Isosporiasis, Katayama fever, Lyme disease, Mange, Malaria Metagonimiasis, Myiasis, Onchocerciasis, Pediculosis, Scabies, Schistosomiasis, Strongyloidiasis, Taeniasis (cause of Cysticercosis), Toxocariasis, Toxoplasmosis, Trichinosis, Trichurias and Trypanosomiasis.
Dependencies are inferred from the claim text.