Thermostable Inhibitors of Activation of the Blood Clotting System Through Contact with Foreign Surfaces
AssigneesSynapse, Inc., Universiteit Maastricht
InventorsTilman Mathias Hackeng, Dennis Peter Leonardo Suijlen, Hendrik Coenraad Hemker, Rafael Jesus Apitz-Castro
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Abstract
The present invention relates to the field of blood clotting. Specifically, the invention relates to particular inhibitors of artificial activation of the blood clotting process through contact with foreign surfaces.
Claims25
A composition comprising at least one calcium-chelating substance with blood clotting inhibition activity and further comprising a thermostable peptide of at most 42 amino acids which inhibits contact activation of the blood clotting system, said peptide comprising within a consecutive sequence of at most about 40 amino acids at least four cysteines, the amino acid Arg or an analog of Arg on a position corresponding to amino acid position 5 in SEQ ID NO:
- 1 and preferably at least the consecutive amino acid sequence Ile-Leu-Met.
Use of a thermostable peptide of at most 42 amino acids which inhibits contact activation of the blood clotting system, said peptide comprising within a consecutive sequence of at most about 40 amino acids at least four cysteines and preferably at least the consecutive amino acid sequence Ile-Leu-Met, for inhibiting activation of the blood clotting system through contact with foreign surfaces.
A thermostable peptide of at most 42 amino acids which inhibits contact activation of the blood clotting system, said peptide comprising within a consecutive sequence of at most about 40 amino acids at least four cysteines, the amino acid Arg or an analog of Arg on a position corresponding to amino acid position 5 in SEQ ID NO:
- 1 and preferably at least the consecutive amino acid sequence Ile-Leu-Met.
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Dependencies are inferred from the claim text.