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AssigneesOregon Health & Science University, Vivoscript, Inc.
InventorsYong Zhu, Shili Wu, Jun Bao, Cong-Qiu Chu
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The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), MSCs, fibroblasts, hematopoietic stem cells, endothelian stem cells, adipocytes, chondrocytes, osteoblasts, osteoclasts and endothelial cells) into chondrogenic cells without introducing exogenous genes to the samples. In particular, the present inventions are directed to transducible materials that are capable of transducing into the biological samples but are not genes or causing genetic modifications. The present inventions also are directed to methods of reprogramming the path of biological samples or treating diseases using the tranducible compositions thereof.
A transducible material comprising an effector domain, wherein the effector domain is a polypeptide, a small molecule, or a polynucleotide, and wherein the polypeptide is selected from the group consisting of Sox9, Sox6, Sox5, c-Myc, Klf4, Mef2C, Trps1, Gli3, Runx2, Dlx5, Dlx6, GATA-6, and Baf60c, and a homologous sequence thereof, and any combination thereof.
A method of identify an effector domain comprising:
Dependencies are inferred from the claim text.