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US 2014/0277577 A1Published application
Pepsinized collagen implants and biomedical uses thereof
AssigneeOrthovita, Inc.
InventorVenkat R. Garigapati
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Abstract
Disclosed are pepsinized collagen implants, such as membranes and sponges, and methods of making them, which entails solubilizing pepsinized collagen in a buffer containing a polyol, e.g., mannitol or sorbitol, wherein the buffer has a substantially neutral pH. Methods of using the pepsinized collagen implants for clinical applications are also disclosed.
Claims22
A method of preparing a collagen implant for use in tissue repair, comprising:
- (a) digesting collagen with pepsin, thus producing pepsinized collagen;
- (b) solubilizing the pepsinized collagen in a buffer composition comprising a polyol, wherein the buffer has a substantially neutral pH;
- (c) drying the thus-solubilized, pepsinized collagen;
- and optionally
- (d) reacting the collagen of (c) with a cross-linking agent, thus producing the collagen membrane.
2 more elements
Dependencies are inferred from the claim text.