Hard-Tissue Implant

A method of use of a hard-tissue implant in a hard tissue of an individual in need thereof, the hard-tissue implant comprising:

• (a) a bulk implant;
• (b) a face being an exterior surface of the bulk implant;
• (c) pillars for implantation into a hard tissue, the pillars being distributed on the face, across an area of at least 80 mm2, and extending distally therefrom, and each pillar being integral to the bulk implant, having a distal end, having a transverse area of (200×200) to (10,000×10,000) μm2, and having a height of 100 to 10,000 μm;
• and
• (d) slots to be occupied by the hard tissue, the slots being defined by the pillars and each slot having a width of 100 to 10,000 μm as measured along the shortest distance between adjacent pillars;
• wherein:
• the hard-tissue implant has a Young's modulus of elasticity of at least 10 GPa, has a ratio of (i) the sum of the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1, does not comprise any part that is hollow, and does not comprise any non-pillar part extending to or beyond the distal ends of any of the pillars;
• the method comprising:
• (1) selecting the hard-tissue implant such that the ratio of (i) the product of (a) the Young's modulus of the hard-tissue implant and (b) the sum of the volumes of the pillars to (ii) the product of (a) the Young's modulus of the hard tissue and (b) the sum of the volumes of the slots is 0.80:1 to 3.8:1;
• and
• (2) implanting the hard-tissue implant in the hard-tissue of the individual.