Treatments of extracellular matrices of the eye

A system for conducting a corrective procedure for an eye, comprising:

• a contact lens structure including at least one channel and at least one illumination fiber, the contact lens being configured for application over at least a cornea of the eye;
• a cross-linking agent source coupled to the at least one channel;
• and
• an illumination source coupled to the at least one illumination fiber,
• wherein the contact lens structure delivers the cross-linking agent to a selected area of the eye via the at least one channel, and
• the contact lens structure delivers photo-activating light from the illumination source to the selected area of the eye via the illumination fiber after the cross-linking agent has been delivered, the photo-activating light including one or more doses necessary for generating cross-linking activity in the selected are of the eye by activating the cross-linking agent and for activating TGF-β isoforms to improve health of extracellular matrices in the selected area of the eye.