Cross-linked coating delivered by a balloon
AssigneeAbbott Cardiovascular Systems Inc.
InventorsJohn Stankus, Mikael Trollsas, Syed Hossainy
Life of this patent
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Abstract
The present invention relates to systems for and corresponding methods of delivering a therapeutic agent to a vessel wall of a body lumen by providing a compound capable of being crosslinked after intraluminal release onto a vessel wall so that the therapeutic agent is temporarily retained at the site of delivery by the crosslinked compound.
Claims15
A system to deliver a therapeutic agent to a vessel wall of a body lumen, comprising:
- (a) an expandable member having a distal end, a proximal end and a working length therebetween;
- (b) a crosslinkable compound disposed along at least a portion of the working length for intraluminal release therefrom after inflation of the expandable member, the crosslinkable compound capable of being crosslinked after intraluminal release on to a vessel wall;
- and
- (c) at least one therapeutic agent disposed along the portion of the working length so as to be temporarily retained by the crosslinkable compound after intraluminal release to the vessel wall.
The system of any of the preceding claims, wherein the at least one therapeutic agent is combined with the crosslinkable compound.
The system of any of the preceding claims, wherein the crosslinkable compound is crosslinked by thermal treatment, optionally wherein the crosslinkable compound crosslinks at or above about 37 degrees Celsius, further optionally wherein the crosslinkable compound is selected from the group consisting of silk-elastin-like protein-based polymers, pluronics F127, pluronics F68, polyNIPAAM, polyNIPAAM-co-acrylic acid, PEG-PEG-PLA-PEG, PLGA-PEG-PLGA, solubilized extracellular matrix, self-assembling peptides, hydroxypropylmethylcellulose, and a combination thereof.
The system of any of the preceding claims, wherein the at least one therapeutic agent is selected from the group consisting of antithrombotics, anticoagulants, antiplatelet agents, anti-lipid agents, thrombolytics, antiproliferatives, anti-inflammatories, agents that inhibit hyperplasia, smooth muscle cell inhibitors, antibiotics, growth factor inhibitors, cell adhesion inhibitors, cell adhesion promoters, antimitotics, antifibrins, antioxidants, antineoplastics, agents that promote endothelial cell recovery, antiallergic substances, viral vectors, nucleic acids, monoclonal antibodies, antisense compounds, oligonucleotides, cell permeation enhancers, radiopaque agent markers, HMG CoA reductase inhibitors, pro-drugs, and combinations thereof.
A method of delivering a therapeutic agent to a vessel wall of a body lumen, comprising:
- providing a system according to any of the preceding claims;
- positioning the expandable member in a body lumen;
- expanding the expandable member to contact the vessel wall for intraluminal release of, the crosslinkable compound on to the vessel wall;
- and
- crosslinking the crosslinkable compound on the vessel wall with the at least one therapeutic agent temporarily retained by the crosslinked compound for delivery to the vessel wall.
Dependencies are inferred from the claim text.