Drug delivery device, method, and system for administration of dual antiplatelet therapy
AssigneeAbbott Cardiovascular Systems Inc.
InventorWeiying Zhao
Life of this patent
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Abstract
A drug delivery device for reducing the likelihood of stent thrombosis following implantation in a subject is provided. A stent is provided including a body having a plurality of struts and one or more coatings applied to the body including at least one polymer, a therapeutic agent for inhibiting restenosis, a loading dose of a first antiplatelet agent and a maintenance dose of the first antiplatelet agent, and a loading dose of a second antiplatelet agent and a maintenance dose of the second antiplatelet agent.
Claims23
An implantable stent comprising:
- a body including a plurality of struts;
- and
- one or more coatings applied to the body comprising
- at least one polymer;
- a therapeutic agent for inhibiting restenosis;
- a loading dose of a first antiplatelet agent and a second antiplatelet agent for administration to tissue in a region proximate to the implantable stent;
- and
- a maintenance dose of the first antiplatelet agent and a maintenance dose of the second antiplatelet agent for administration to tissue in a region proximate to the implantable stent.
A method for reducing a likelihood of stent thrombosis, comprising:
- providing a stent having a body including a plurality of struts, and one or more coatings applied to the body comprising at least one polymer;
- a therapeutic agent for inhibiting restenosis;
- a loading dose of a first antiplatelet agent and a second antiplatelet agent;
- and a maintenance dose of the first antiplatelet agent and the second antiplatelet agent;
- implanting the stent inside a blood vessel of a subject;
- administering the loading dose of the first antiplatelet agent and the second antiplatelet agent to tissue located proximate the implanted location of the stent;
- and
- administering the maintenance dose of the first antiplatelet agent and the second antiplatelet agent to tissue located proximate the implanted location of the stent.
A dual antiplatelet therapy system, comprising:
- an inflatable deployment device coated with a loading dose of a first antiplatelet agent and a loading dose of a second antiplatelet agent, the inflatable deployment device being configured to release the first and second loading dose when the inflatable deployment device is in an inflated configuration to tissue located proximate the inflatable deployment device;
- and
- a stent disposed on the inflatable deployment device, the stent comprising a plurality of struts, a coating comprising at least one polymer adhered to the body, a therapeutic agent for inhibiting restenosis, and a maintenance dose of a third antiplatelet agent and a fourth antiplatelet agent, the stent being configured to continuously release the maintenance dose to tissue located proximate the stent following an implantation of the stent within a subject.
A method for reducing a likelihood of stent thrombosis, comprising:
- providing an inflatable deployment device coated with a loading dose of a first antiplatelet agent and a loading dose of a second antiplatelet agent;
- providing a stent disposed on the inflatable deployment device, the stent comprising a plurality of struts, a coating comprising at least one polymer adhered to the body, a therapeutic agent for inhibiting restenosis, and a maintenance dose of a third antiplatelet agent and a fourth antiplatelet agent;
- administering the loading dose of the first and second antiplatelet agents upon inflation of the inflatable deployment device to tissue within a vessel of a patient located proximate the inflatable deployment device;
- and
- administering the maintenance dose of the third and fourth antiplatelet agents after deployment of the stent to tissue within the vessel of the patient located proximate the deployed stent.
Dependencies are inferred from the claim text.