Systems and methods for selectively migrating cells using electric fields
AssigneeThe Regents of the University of California
InventorsMin ZHAO, Junfeng FENG, Lei ZHANG
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Abstract
Systems and methods are provided for migrating cells implanted or endogenous in tissue. The system may include first and second delivery electrodes configured for insertion in tissue and a direct current (DC) power source operatively coupled to the first and second delivery electrodes. The system further may include a programmable controller operatively coupled to the DC power source, wherein the programmable controller is programmed to direct the DC power source to deliver an electric field between the first delivery electrode and the second delivery electrode at a stimulation to nonstimulation ratio sufficient to cause the cells to migrate within tissue selectively.
Claims23
A system for migrating cells in tissue, the system comprising:
- first and second delivery electrodes configured for insertion in tissue;
- a direct current (DC) power source operatively coupled to the first and second delivery electrodes;
- and
- a programmable controller operatively coupled to the DC power source, the programmable controller programmed to direct the DC power source to deliver an electric field between the first delivery electrode and the second delivery electrode at a stimulation to nonstimulation ratio sufficient to cause the cells to migrate within tissue.
A method for migrating cells using an electric field, the method comprising:
- inserting first and second delivery electrodes in tissue, the first and second delivery electrodes operatively coupled to a direct current (DC) power source;
- and
- delivering an electric field between the first delivery electrode and the second delivery electrode, via the DC power source, at a stimulation to nonstimulation ratio sufficient to cause the cells to migrate within tissue.
Dependencies are inferred from the claim text.