Methods, compositions, and devices for the occlusion of cavities and passageways
AssigneesBoard of Regents, The University of Texas System, Applied Cardiovascular Solutions, LLC
InventorsF. Javier Otero, Joseph J. Beaman, Krishnendu Roy, Andrew Zimbroff
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Abstract
Provided herein are methods, compositions, and devices for occluding cavities or passageways in a patient, in particular cavities or passageways in the cardiovascular system of a patient, such as the LAA of a patient's heart. The methods, compositions, and devices can be used to percutaneously occlude the LAA, decreasing the risk of thromboembolic events associated with AF.
Claims23
A method of occluding the left atrial appendage (LAA) of a patient comprising injecting a crosslinkable biomaterial into the LAA of the patient;
- wherein the crosslinkable biomaterial crosslinks in situ in the LAA to form a biocompatible polymeric matrix;
- wherein the biocompatible polymeric matrix exhibits an equilibrium swelling ratio of less than about 8;
- and
- wherein the biocompatible polymeric matrix has a degradation rate effective to permit the LAA to be sealed via endothelialization prior to erosion of the biocompatible polymeric matrix.
A method of occluding the LAA of a patient comprising
- (a) advancing a delivery catheter which comprises (i) a proximal region;
- (ii) a distal region comprising a distal tip;
- (iii) a first lumen extending from the proximal region to the distal region;
- and (iv) an occluding element positioned in proximity to the distal tip;
- percutaneously through the patient's vasculature, such that the distal tip of the delivery catheter reaches the patient's left atrium;
- (b) advancing the distal tip of the delivery catheter into the LAA, such that the occluding element is configured to seal the LAA;
- and
- (c) injecting a crosslinkable biomaterial into the LAA of the patient, wherein the crosslinkable biomaterial crosslinks in situ in the LAA to form a biocompatible polymeric matrix.
A multi-lumen delivery catheter comprising:
- a proximal region;
- a distal region comprising a distal tip;
- a first lumen extending from the proximal region to the distal region;
- a second lumen extending from the proximal region to the distal region;
- and
- an occluding element positioned in proximity to the distal tip.
Dependencies are inferred from the claim text.