Soft tissue repair allografts and methods for preparing same
AssigneeMusculoskeletal Transplant Foundation
InventorsMichael Locarno, Bryan J. Choi, Mahn-Dan Ngo
Life of this patent
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Abstract
Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. One allograft is made from decellularized dermal tissue and constitutes a collagen matrix having substantially uniform density and porosity. Another allograft is a hybrid bilayer tissue form that is made from decellularized dermal and adipose tissues. Methods for making both allografts are also disclosed.
Claims42
A method for making an allograft dermal tissue form, comprising the steps of:
- providing a donor tissue including skin having (a) an epidermis, (b) a dermis underlying the epidermis, the dermis including a papillary dermis adjacent the epidermis, a reticular dermis distal to the epidermis, and a papillary-reticular dermis interface PRI between the papillary dermis and reticular dermis, and (c) a dermis-epidermis junction between the papillary dermis and epidermis;
- and a hypodermis adipose tissue underlying the reticular dermis RD, distal to the papillary-reticular dermis interface;
- making a first cut into the reticular dermis at a first location distal the papillary-reticular dermis interface, and along a first plane substantially parallel to the papillary-reticular dermis interface;
- removing the hypodermis from the reticular dermis along the first cut to form a first exposed surface on a remaining portion of the donor tissue;
- making a second cut into the papillary dermis at a second location proximate the dermis-epidermis junction, and along a second plane substantially parallel to the papillary-reticular dermis interface and the first plane;
- removing the epidermis, dermis-epidermis junction and a portion of the papillary dermis from the remaining portion of the donor tissue to form a second exposed surface on a remaining portion of the dermis opposite the first exposed surface, wherein the first and second locations are selected such that the remaining portion of the dermis constitutes a collagen matrix having substantially uniform density and porosity between the first exposed surface and the second exposed surface.
An allograft dermal tissue form for use in surgical procedures, comprising a portion of dermal tissue having a first exposed surface formed by a first cut and a second exposed surface formed by a second cut opposite said first exposed surface, said portion of dermal tissue constituting a collagen matrix having substantially uniform density and porosity between said first exposed surface and said second exposed surface.
A method for forming an allograft hybrid bilayer tissue form, comprising the steps of:
- providing a donor tissue including a skin having (a) an epidermis and (b) a dermis underlying the epidermis, the dermis including a papillary dermis adjacent the epidermis, a reticular dermis distal to the epidermis, and a papillary-reticular dermis interface between the papillary dermis and reticular dermis;
- and a hypodermis adipose tissue underlying the reticular dermis;
- making a cut into the reticular dermis at a location proximate the hypodermis, and along a plane substantially parallel to the papillary-reticular dermis interface;
- and
- removing the hypodermis and a portion of the reticular dermis attached to the hypodermis to form said allograft hybrid bilayer tissue form such that said allograft hybrid bilayer tissue form includes both a dermal side and an adipose side.
An allograft hybrid bilayer tissue form for use in surgical procedures, comprising a dermal side and an adipose side.
Dependencies are inferred from the claim text.