Conduits for enhancing tissue regeneration

An apparatus to enhance bone regeneration, comprising:

• a first number of segments formed from a material comprising calcium phosphate, at least one of the segments having a first open end configured for ingress of physiological signals proximal to a tissue regeneration site that promote multipotent mesenchymal cell differentiation and egress of mesenchymal cell differentiation products;
• and
• a second number of segments formed from a material comprising calcium phosphate, at least one of the segments having a second open end configured to penetrate a source of multipotent mesenchymal cells and configured for egress of the physiological signals and ingress of the mesenchymal cell differentiation products;
• wherein the segments form an extravascular or transvascular conduit to enhance the bone regeneration.

A system to enhance bone regeneration, comprising:

• a number of conduit segments having a first open end configured for penetration of an intramedullary bone cavity and ingress of multipotent mesenchymal cells and/or products thereof;
• the number of conduit segments having a second open end configured for egress of the multipotent mesenchymal cells and/or the products thereof proximal to a site of a partitioned bone;
• and
• a bioactive, biocompatible implant to at least partially fill a void of the partitioned bone;
• wherein the number of conduit segments and the bioactive, biocompatible implant form a conduit for the multipotent mesenchymal cells to enhance the bone regeneration to fill a remaining void of the partitioned bone with new bone.