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US 2014/0276589 A1Published application
Microarray for delivery of therapeutic agent and methods of use
AssigneeCorium International, Inc.
InventorsDanir Bayramov, Guohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Parminder Singh, Doug Bourne
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Abstract
Microstructure arrays and methods for using and manufacturing the arrays are described.
Claims35
A microstructure apparatus, comprising:
- an approximately planar substrate having a first surface and a second surface opposed thereto;
- and
- a microstructure array comprising a plurality of microstructures contacting the first surface of the substrate and fixedly attached thereto, the microstructures being formed of a polymer matrix comprising at least one of:
- (a) a water insoluble, biodegradable polymer, and at least one therapeutic agent;
- (b) at least one low molecular weight polymer, at least one high molecular weight polymer, and at least one therapeutic agent;
- (c) at least one biodegradable polymer, a hydrophilic component, and at least one therapeutic agent;
- or
- (d) at least one polymer and at least one therapeutic agent, wherein a ratio of therapeutic agent to polymer in the matrix is low;
- and
- wherein release of the therapeutic agent from the polymer matrix is sustained for a period of at least about 1-144 hours.
7 more elements
A method of making a sustained release microstructure apparatus, comprising:
- dissolving or suspending a therapeutic agent in a solvent to form a therapeutic agent solution or suspension;
- dissolving at least one water insoluble, biodegradable polymer in a solvent to form a polymer solution;
- mixing the therapeutic agent solution or suspension and the polymer solution or suspension to form a polymer matrix solution or suspension;
- dispensing the polymer matrix solution or suspension on a mold having an array of microstructure cavities;
- filling the microstructure cavities in the mold;
- removing excess solution or suspension polymer matrix on the mold surface;
- and
- drying the matrix to form a plurality of microstructures;
- dispensing a basement or backing layer on the mold surface;
- drying the basement or backing layer.
7 more elements
A method of modulating an initial release rate of a therapeutic agent from a microstructure apparatus comprising a plurality of microstructures formed of a polymer matrix comprising at least one polymer and at least one therapeutic agent, the method comprising at least one of:
- (a) wherein the at least one polymer comprises at least one high molecular weight polymer and at least one low molecular weight polymer, adjusting a ratio of the high molecular weight polymers to low molecular weight polymers in the polymer matrix to achieve a desired initial release rate of therapeutic agent from the polymer matrix;
- (b) adjusting a ratio of therapeutic agent to the at least one polymer in the polymer matrix;
- (c) adding at least one hydrophilic component to the polymer matrix;
- and/or
- (d) selecting a solvent for preparing the polymer matrix that provides a desired initial release rate.
2 more elements
Dependencies are inferred from the claim text.