Infusion System for the Controlled Delivery of Therapeutic Agents

A system for the intravenous delivery of a drug to a patient, the drug delivered at a flow rate within a predetermined range, the system comprising:

• a reservoir configured to contain a solution comprising the drug;
• a rigid housing containing the reservoir,
• a catheter having a first end and a second end;
• wherein the first end is connected to the reservoir;
• an expandable drive balloon disposed within the rigid housing in at least a partially non-expanded state;
• wherein the drive balloon includes a first section and a second section, each section separated by a releasable valve;
• wherein the first section includes a liquid and the second section includes at least one reactant configured to chemically react with the liquid to produce a gas which expands the drive balloon, wherein when the valve is released, the liquid from the first section mixes with the reactants(s) in the second section to produce the gas which expands the drive balloon to exert a pressure from the drive balloon to the reservoir to push the drug solution into the catheter, and
• a hollow needle having a proximal end and a distal tip;
• wherein the proximal end is coupled to the second end of the catheter and the distal tip is configured to deliver the drug solution to a blood vessel of the patient;
• and
• wherein the pressure exerted on the reservoir and a fluidic resistance of at least one of the catheter or the hollow needle are configured to deliver the drug solution to the patient at a flow rate within the pre-determined range.