Compositions and methods for transdermal delivery of tertiary amine drugs
AssigneeNoven Pharmaceuticals, Inc.
InventorsJun Liao, Takito Shima, Puchun Liu, Steven Dinh
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Abstract
Described are transdermal drug delivery systems for the transdermal administration of tertiary amine drugs, such as rivastigmine, fentanyl or rotigotine, comprising a polymer matrix comprising a free base form of the drug and at least one carboxyl group-containing compound. In some embodiments, the systems include a rate-controlling membrane and a skin-contacting face adhesive apart from the polymer matrix.
Claims30
A transdermal drug delivery system comprising a polymer matrix comprising the free base form of a tertiary amine drug and at least one carboxyl group-containing compound, wherein the relative amounts of free base and carboxyl group-containing compound is such that greater than 50% of the free base is associated with a carboxylic acid group to form a salt.
A method of making a transdermal drug delivery system for a tertiary amine drug, comprising forming a polymer matrix comprising a free base form of the tertiary amine drug and at least one carboxyl group-containing compound, wherein the relative amounts of free base and carboxyl group-containing compound is such that greater than 50% of the free base is associated with a carboxylic acid group to form a salt.
A transdermal drug delivery system comprising a polymer matrix comprising the free base form of a tertiary amine drug, a rate-controlling membrane, and a face adhesive comprising a carboxyl group-containing compound.
A method of making a transdermal drug delivery system for a tertiary amine drug, comprising combining
- a polymer matrix comprising a free base form of the tertiary amine drug;
- a rate-controlling membrane;
- and
- a face adhesive comprising a carboxyl group-containing compound.
Dependencies are inferred from the claim text.