Method of treating infections, diseases or disorders of nail unit
AssigneeHallux, Inc.
InventorsJay E. Birnbaum, Bruce Lerman
Life of this patent
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Abstract
Methods for the subungual treatment of diseases or disorders of the nail unit including infections, especially fungal infections, and nail psoriasis involving the toenails and fingernails are described. The methods provide a technique for placement of a drug-containing composition subungually with reduced risk of hematoma formation and improved patient comfort.
Claims46
A method for treating a disease or disorder of the nail unit, comprising:
- providing a device comprised of an applicator and a composition comprising an active agent;
- inserting the applicator subungually;
- and
- depositing the composition subungually.
The method of any preceding claim, wherein the method further comprises after said inserting and prior to said depositing, withdrawing the needle or cannula to a region between the distal edge of the lunula and the hyponychium.
A dosing regimen for treating a disease or disorder of the nail unit, comprising:
- administering subungually a first device and a second device, said first and second devices each comprised of a biodegradable polymeric matrix and an active agent dispersed in the matrix;
- waiting a period of time;
- and
- administering a third device and optionally a fourth device, said third device and optional fourth device comprised of a biodegradable polymeric matrix and an active agent dispersed in the matrix;
- whereby said waiting a period of time achieves release of the active agent from the matrix at a rate to maintain a concentration of active agent in a substantial portion of the nail bed above the minimum inhibitory concentration;
- and
- whereby said administering comprises depositing said devices at a position between a lateral nail fold and a longitudinal midline of the nail plate.
Dependencies are inferred from the claim text.