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AssigneeCorium International, Inc.
InventorsGuohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Parminder Singh
Estimating the term…
Provided herein is a microstructure array comprising a plurality of dissolving microstructures such as microprojections attached to a base. The plurality of microstructures comprise an active agent in a biocompatible and water-soluble matrix, where the water-soluble matrix preferably comprises a polysaccharide polymer and a sugar alcohol, and the base typically comprises a non-water soluble matrix. The plurality of microstructures, upon penetration of the subject's skin, undergo dissolution to deliver the active agent. Also provided are related microstructure formulations, in dried and liquid form, methods for preparing the above-described microstructure arrays, and methods for administering an active agent by application of a microstructure array as provided herein to a subject's skin, among other features.
A microstructure array comprising an approximately planar base and a plurality of biodegradable microstructures, each microstructure having an attachment point to the base and a distal tip to penetrate a subject's skin, wherein
A liquid formulation suitable for forming a plurality of dissolving microstructures, the liquid formulation comprising an active agent, a polysaccharide and a sugar alcohol in a buffer, wherein the liquid formulation comprises from about 1-30% by weight polysaccharide, from about 1-30% by weight sugar alcohol, and from about 0.05-20% by weight active agent.
A method of making a microstructure array, comprising:
Dependencies are inferred from the claim text.