Apparatus and method for tissue rejuvenation
AssigneePlum Systems Co.
InventorAlexandra Alvarez
Life of this patent
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Abstract
A method for treating skin in a subject is disclosed. The method comprises the steps of administering a stem cell composition into a target body site in the subject by subcutaneous, intradermal or topical delivery, and contacting the target body site with a treatment device designed for introducing CO2 into subcutaneous tissue, wherein the CO2 and the stem cell composition are provided in an amount effective for treating a skin-related disorder or improving the condition of skin. Also disclosed is a method for generating induced pluripotent stem cells (iPSCs) in a subject.
Claims30
A method for treating skin-related disorder or improving the condition of skin in a subject, comprising:
- administering a stem cell composition into a target body site in the subject by subcutaneous, intradermal or topical delivery, and
- administering CO2 to the target body site by subcutaneous or intradermal administration,
- wherein the CO2 and the stem cell composition are provided in an amount effective for treating said a skin-related disorder or improving the condition of skin.
A method for generating induced pluripotent stem cells (iPSCs) in a subject, comprising:
- subjecting said subject to a CO2 treatment comprising:
- contacting a target body surface of said subject with a skin treatment device comprising a plurality of hollow needles attached to a contact surface of a housing;
- and a CO2 source in fluid communication with at least one of said plurality of hollow needles;
- applying pressure to said housing such that one or more of the plurality of hollow needles penetrate an epidermis or an outermost layer of cell in said target body surface;
- and,
- applying an effective amount of CO2 to said subject through said plurality of hollow needles for an effective period of time to generate iPSCs.
A method for treating a disorder in a subject, comprising:
- administering a stem cell composition into a target body site in the subject by subcutaneous, intradermal or topical delivery, and
- administering CO2 to the target body site by subcutaneous or intradermal administration,
- wherein the CO2 and the stem cell composition are provided in an amount effective for treating said disorder, wherein said disorder is selected from the group consisting of psoriasis, Reynaud's disease, a necrotising skin infection, alopecia areata and rheumatoid arthritis.
A method for treating a skin-related condition in a subject, comprising subjecting the subject to CO2 treatment that comprises the step of:
- contacting a target body surface of the subject with a skin treatment device comprising:
- plurality of hollow needles attached to a contact surface of a housing;
- and a CO2 source in fluid communication with at least one of said plurality of hollow needles;
- applying pressure to the housing such that one or more of the plurality of hollow needles penetrate an epidermis or an outermost layer of cell in the target body surface;
- and
- applying an effective amount of CO2 to the subject through the plurality of hollow needles for an effective period of time to generate a low-pH environment adapted to induce reprogramming of somatic cells into induced pluripotent stem cells.
Dependencies are inferred from the claim text.