Systems and methods for treating glaucoma

A system for treating glaucoma, comprising:

• a cannula body configured to be positioned in an area of Schlemm's canal;
• an illumination guide extending along the cannula body;
• at least one drug source coupled to the cannula body, the at least one drug source including a drug that promotes outflow of aqueous humor through the trabecular meshwork and into Schlemm's canal;
• a cross-linking agent source coupled to the cannula body;
• and
• an illumination source coupled to the illumination guide, wherein the cannula body delivers the drug from the at least one drug source to the area of Schlemm's canal, and in response to changes in the outflow of aqueous humor, delivers the cross-linking agent to the area of Schlemm's canal, and
• the illumination guide delivers photo-activating light from the illumination source to the area of Schlemm's canal after the cross-linking agent has been delivered, the photo-activating light generating cross-linking activity in the area of Schlemm's canal by activating the cross-linking agent, thereby stabilizing changes in the area of Schlemm's canal.