Electrophorectic drug coated balloon and conductive polymer coating
OwnerStephen D. Pacetti, Dariush Davalian +4inventors
InventorsStephen D. Pacetti, Dariush Davalian, John Stankus, Mikael Trollsas, Syed Hossainy, Michael Ngo
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Abstract
Balloon catheter configured to deliver a therapeutic agent upon provision of electric potential to the balloon, the catheter comprising an electrode disposed proximate the outer surface of the expandable member, a coating disposed on at least a portion of the outer surface, the coating including a therapeutic agent; and a power source in electrical communication with the electrode is described.
Claims14
A catheter for intraluminal delivery of a therapeutic agent to a subject comprising:
- an elongate shaft having a proximal end portion, a distal end portion, and an inflation lumen defined therebetween;
- an expandable member coupled at the distal end portion of the elongate shaft, the expandable member having a proximal end, a distal end, an outer surface, and an interior chamber defined therein;
- an electrode disposed proximate the outer surface of the expandable member;
- a coating disposed on at least a portion of the outer surface, the coating including a therapeutic agent;
- and
- a power source in electrical communication with the electrode, optionally a cathode.
The catheter of any of the preceding claims, wherein the coating includes an emulsifier, optionally wherein the emulsifier is an anionic surfactant optionally selected from the group consisting of selected from the group consisting of phosphatidylglycerols, phosphatic acids, lysophospholipids, saturated fatty acids and unsaturated fatty acids or a polyionic polymer selected from the group consisting of polycationic polymers and polyanionic polymers.
The catheter of any of the preceding claims, wherein the electrode comprises at least one conductive polymer and further wherein the electrode is disposed as a coating configured to absorb ions and water during temporary application of current or voltage to the conductive polymer, optionally wherein the conductive polymer is doped, further optionally wherein the at least one conductive polymer is selected from the group comprising polypyrrole, polyacetylene derivatives, poly(phenylene sulfide), polythiopene, and poly(3,4-ethylenedioxythiopene), and further optionally wherein the therapeutic agent is disposed in the coating in a matrix arrangement.
The catheter of any of the preceding claims, wherein the coating further comprises a plasticizer optionally selected from the group consisting of glycerin, polyethylene glycol, polypropylene glycol, propylene glycol, tweens, N-methylpyrrolidone, dimethyl sulfoxide, benzyl benzoate, ethyl benzoate, benzyl alcohol, and phenoxyethanol.
The catheter of any of the preceding claims, wherein the coating is disposed as a first layer comprising a first conductive polymer and a first therapeutic agent and a second layer comprising a second conductive polymer and a second therapeutic agent, optionally wherein the first conductive polymer is different from the second conductive polymer and further optionally wherein the first therapeutic agent is different from the second therapeutic agent.
A catheter for intraluminal delivery of a therapeutic agent to a space within a patient comprising:
- an elongate shaft having a proximal end portion, a distal end portion, and an inflation lumen defined therebetween;
- an expandable member coupled at the distal end portion of the elongate shaft, the expandable member having a proximal end, a distal end, an outer surface, and an interior chamber defined therein;
- a coating disposed on at least a portion of the outer surface, the coating including a therapeutic agent and a conductive polymer, wherein the conductive polymer is piezoelectric.
Dependencies are inferred from the claim text.