Novel Enhanced Device and Composition for Local Drug Delivery
AssigneeTeleflex Medical Incorporated
InventorsJohn C. Victor, David T. Rowe, Jeffrey Vitullo
Life of this patent
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Abstract
A medical device for delivering a reagent, such as a pharmaceutical agent, a diagnostic agent, a nutrient, or another type of reagent, to an intravascular or intralumenal location, is disclosed. The medical device has a coating, where exposing the coating to light severs a photosensitive bond that releases the reagent into the immediate vicinity of the location.
Claims27
A medical device configured for delivering at least one reagent to an intraluminal location, or other location in the body, the medical device comprising a surface and a coating, wherein the coating is modified by a photosensitive linker that covalently binds the at least one reagent agent, the photosensitive linker comprising:
- (a) a first functional group that covalently binds the pharmaceutical agent;
- (b) a photosensitive moiety that is adapted to cleaved by exposure to light;
- and
- (c) a second functional group that maintains contact with the coating;
- wherein the coating on the medical device is configured to deliver and, with exposure to light, release the at least one reagent in an effective amount that contacts the location.
A method for delivering, or releasing, at least one reagent to an intraluminal location, or other location in the body, comprising the step of positioning a medical device in a lumen;
- wherein the medical device is configured for delivering at least one reagent to an intraluminal location, or other location in the body, the medical device comprising a surface and a coating, wherein the coating is modified by a photosensitive linker that covalently binds the at least one reagent, the photosensitive linker comprising:
- (a) a first functional group that covalently binds the reagent;
- (b) a photosensitive moiety that is adapted to cleaved by exposure to light;
- and
- (c) a second functional group that maintains contact with the coating;
- wherein the coating on the medical device is configured to deliver and, with exposure to light, release the at least one reagent in an effective amount that contacts the location;
- and,
- further comprising the step of irradiating the coating with a photocleavably effective amount of radiation.
Dependencies are inferred from the claim text.