Implantable Devices with Delivery Systems and Methods for Blocking Digestive Neurohormonal Pathways in Mammals

A gastrointestinal implant and delivery system comprising:

• an implantable liner, the implantable liner having a substantially flexible proximal cuff, a substantially flexible distal cuff, and a substantially flexible conduit with a longitudinally extending length between the proximal cuff and distal cuff;
• an opening extending through the proximal cuff to the distal cuff;
• a delivery system;
• the delivery system having a handle, an attachment rod, a first nose cone and a second nose cone;
• the first nose cone having a longitudinal extending body, the longitudinal extending body having an outer surface and at least one guide channel recessed from the outer surface;
• the second nose cone having a longitudinal extending body, the longitudinal extending body having an outer surface and at least one guide channel recessed from the outer surface;
• the attachment rod having a longitudinally extending length with a first end and a second end, the first nose cone connected to the attachment rod a first location proximate to the first end of the attachment rod;
• and
• the second nose cone connected to the attachment rod at a second location, a longitudinal spacing between the first nose cone and a second nose cone approximating the longitudinally extending length of the substantially flexible conduit.

A method of deploying an implantable liner into a gastrointestinal tract comprising the steps of:

• measuring an inner diameter of the gastrointestinal tract at a first location and a second location;
• selecting an implantable liner having a longitudinal length that is sized and configured to extend from the first location to the second location, the implantable liner having a first cuff and a second cuff, the first cuff being sized and configured to fit within the inner diameter of the gastrointestinal tract at the first location, the second cuff being sized and configured to fit within the inner diameter of the gastrointestinal tract at the second location;
• selecting a delivery system for carrying the implantable liner, the delivery system having a first nose cone and a second nose cone, the first and second nose cones each including at least one guide channel;
• inserting the implantable liner and the delivery system into the inner diameter of the gastrointestinal tract;
• positioning the implantable liner and the delivery system within the gastrointestinal tract wherein the first cuff is positioned proximate to the first location within the gastrointestinal tract and the second cuff is positioned proximate to the second location within the gastrointestinal tract;
• securing the first cuff of the implantable liner to a wall of the gastrointestinal tract at the first location using the guide channel on the first nose cone;
• securing the second cuff of the implantable liner to the wall of the gastrointestinal tract at the second location using the guide channel on the second nose cone;
• and
• withdrawing the delivery system to leave the implantable liner within the gastrointestinal tract.