Trans-sclera portal for delivery of therapeutic agents
AssigneeAbbott Medical Optics Inc.
InventorsDaniel J. Urbaniak, John J. Stankus, Syed Hossainy, James Su, Mikael Trollsas
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Abstract
A portal through the sclera for delivery of an effective amount of therapeutic agent to the back of the eye.
Claims46
An implantable shunt for repeated injection of ophthalmic pharmaceutical treatments into an eye, comprising:
- a partition wall that is arranged, upon implantation of the shunt into the eye, to provide separation between the inside and outside of the eye;
- and
- at least one of a healing agent, a catalyst, and a reactive agent included with the partition wall.
An implantable shunt for delivery of an ophthalmic therapeutic agent into an eye, comprising a swell loadable polymeric ocular insert with a micron scale tab that, when inserted into the eye, is configured to extend through the sclera as an external mass transport channel.
A system for delivery of an effective amount of a therapeutic agent to the back of an eye, comprising:
- a swell loadable polymeric ocular insert with a micron scale tab that, when inserted into the eye, extends through the sclera as an external mass transport channel and presents a wicking window into the sclera;
- and
- a drug-delivering contact lens that covers the insert when worn, the contact lens having a lens body formed of a block copolymer with a periodic nanostructure of therapeutic agent-miscible domains interspersed among a hydrogel matrix and impregnated with a therapeutic agent.
A method of treating a patient's eye, comprising:
- surgically implanting in the eye a shunt comprising a partition wall;
- injecting a dose of therapeutic agent into the eye by inserting a needle through the partition wall of the shunt into the interior of the eye and removing the needle;
- thereafter, injecting a second dose of therapeutic agent into the eye by inserting a needle through the partition wall of the shunt into the interior of the eye and removing the needle.
A method of treating a patient's eye, comprising:
- surgically implanting in the eye a swell loadable polymeric ocular insert with a micron scale tab that extends through the sclera as an external mass transport channel;
- and
- placing a therapeutic agent in contact with the ocular insert to thereby load the insert with the agent.
A drug-delivering contact lens system for placement in an eye, comprising:
- a removable lens body comprising therapeutic receiving domains;
- a therapeutic agent impregnated into the therapeutic agent receiving domains;
- a transport device implantable in the eye and capable of absorbing the therapeutic agent in a presence of the removable lens body external to the eye, and capable of delivering the therapeutic agent to an interior portion of the eye.
Dependencies are inferred from the claim text.