Devices, methods and kits for delivery of therapeutic materials to a pancreas

An apparatus, comprising:

• a handle;
• an inner catheter coupled to the handle;
• an outer catheter movably coupled to the handle, the outer catheter defining a first lumen in fluid communication with a distal opening and configured to introduce a therapeutic agent through the distal opening and into one or more target pancreatic arteries, and a second lumen configured to receive at least a portion of the inner catheter;
• a first occlusion element coupled to the inner catheter;
• a second occlusion element coupled to the outer catheter, the second occlusion element being disposed proximal of the first occlusion element;
• and
• an actuator coupled to the handle and configured to move the outer catheter relative to the handle between a first position in which the second occlusion element is at a first distance from the first occlusion element and a second position in which the second occlusion element is at a second distance from the first occlusion element, the second distance being greater than the first distance

A kit, comprising:

• a catheter device including a handle, an outer catheter movably coupled to the handle, an inner catheter coupled to the handle, a distal occlusion element coupled to the inner catheter, a proximal occlusion element coupled to the outer catheter, and an actuator coupled to the handle, the outer catheter defining a first lumen in fluid communication with a distal opening configured to introduce one or more therapeutic agent to one or more target pancreatic arteries, and a second lumen configured to receive at least a portion of the inner catheter,
• the catheter device including an actuator coupled to the handle and configured to move the outer catheter relative to the inner catheter such that a distance between the distal occlusion element and the proximal occlusion element varies;
• and
• one or more therapeutic agent for delivery to a pancreas via the catheter device.