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US 2014/0276107 A1Published application
Photodynamic diagnosis
AssigneePhotocure ASA
InventorKetil Widerberg
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Abstract
This invention relates to the diagnosis of abnormalities of the epithelial-lined surface of the esophagus and, in particular, to the use of esters of 5-aminolevulinic acid (5-ALA) in methods of photodynamic diagnosis (PDD) of Barrett's esophagus and in diagnostic methods which monitor the progression of the disease with high specificity.
Claims15
A method of photodynamic diagnosis of an abnormality of the epithelial lining of the esophagus, said method comprising the following steps:
- (a) administering to a subject a 5-ALA ester, or pharmaceutically acceptable salt thereof;
- (b) if necessary, waiting for a time period necessary for the 5-ALA ester or pharmaceutically acceptable salt thereof to be converted into a photosensitizer and achieve an effective tissue concentration at the desired target site in the esophagus;
- (c) exposing the epithelial lining of the esophagus to light whereby to photoactive the photosensitizer;
- and
- (d) detecting a fluorescence intensity indicative of said abnormality.
2 more elements
Dependencies are inferred from the claim text.