Methods for the non-invasive determination of heart and pulmonary pressures
OwnerGhassan S. Kassab, Yunlong Huoinventors
Life of this patent
Estimating the term…
Abstract
The disclosure of the present application provides methods for the noninvasive determination of cardiac and pulmonary pressures based off of patient-specific medical images and one or more computations. In one exemplary embodiment, the method comprises noninvasively generating a patient-specific medical image of at least a portion of a heart, determining a free vibration measurement from the left ventricular free wall based on the patient-specific image, and performing at least one computation using the free vibration measurement to noninvasively determine a cardiac or pulmonary pressure.
Claims20
A method for noninvasively determining one or more pressure measurements comprising the steps of:
- generating a patient-specific medical image of at least one portion of a heart of a patient noninvasively;
- determining at least one measurement from a portion of the heart in the patient-specific medical image;
- and
- performing one or more computations using the measurement to noninvasively determine at least one targeted pressure within one or more portions of the heart and/or an adjacent vessel.
A method for noninvasively determining right ventricular systolic pressure comprising the steps of:
- determining a pressure gradient based on blood flow velocity measurements through the right ventricle of a heart;
- determining left ventricular systolic pressure by noninvasively measuring aortic pressure;
- and
- assessing the pressure difference across an interventricular septum in view of the left ventricular systolic pressure to determine right ventricular systolic pressure.
A method for noninvasively determining one or more cardiac pressure measurements comprising the steps of:
- generating a patient-specific medical image of at least one portion of a heart noninvasively through magnetic resonance imaging or external ultrasound;
- obtaining at least one measurement related to the position of the left ventricular free wall and the interventricular septum from the patient-specific medical image;
- determining at least a free vibration measurement from a free wall of a left ventricle of the heart in the patient-specific medical image;
- determining end-diastolic Young's modulus of the left ventricular free wall using the free vibration measurement;
- determining patient-specific material parameters of the heart in diastolic strain energy function through numerical optimization (inverse method) such that a Young's modulus value from strain energy function is derived that is substantially equal to the value of the end-diastolic Young's modulus of the left ventricular free wall determined from the free vibration measurement;
- determining the left ventricular end-diastolic pressure by iterative solution such that a predicted left ventricular free wall position substantially matches the measurements related to the left ventricular free wall position;
- and
- determining right ventricular end-diastolic pressure by iterative solution such that a predicted end-diastolic interventricular septum position substantially matches the measurements related to the position of the interventricular septum.
Dependencies are inferred from the claim text.