Devices and Methods For Monitoring Oxygenation During Treatment With Delivery Of Nitric Oxide

A device for calculating and monitoring oxygenation index during treatment with delivery of nitric oxide comprising:

• a first inlet to be placed in fluid communication with a therapeutic gas supply comprising nitric oxide or a nitric oxide-releasing agent;
• a second inlet to be placed in fluid communication with a flow of breathing gas;
• an outlet to be placed in fluid communication with the first inlet, the second inlet, and a patient;
• a proximal pressure transducer for determining mean airway pressure;
• a FiO2 measurement means for measuring fraction of inspired oxygen (FiO2);
• an oxygen measurement means for measuring one or more oxygen measurements selected from the group consisting of arterial oxygen saturation (SaO2), peripheral oxygen saturation (SpO2) and partial pressure of oxygen in arterial blood (PaO2);
• a signal processor capable of calculating oxygenation index based upon a mean airway pressure measurement obtained from the proximal pressure transducer, an oxygen measurement obtained from the oxygen measurement means, and a FiO2 measurement obtained from the FiO2 measurement means;
• and
• a display.