Systems and methods for determining and delivering radiation treatment plans

A computer-implemented method for generating a radiation treatment plan, the method comprising:

• reading a modular radiation dose kernel that defines a three dimensional radiation isocenter dose formed from a sum of a plurality of radiation beams;
• reading data that defines a three dimensional closed surface representing a lesion;
• and
• generating a radiation treatment plan comprising:
• determining a three dimensional radiation isocenter dose from the loaded radiation dose kernel;
• logically dividing the three dimensional closed surface representing a biological object such as a whole organ, a lesion, a critical structure, a tissue, or a population of cells, into a plurality of treatment slices;
• determining and optimizing an initial path plan for moving the three dimensional radiation isocenter dose through each treatment slice for each of the treatment slices;
• and
• determining and optimizing a final path plan for moving the three dimensional radiation isocenter dose through all of the treatment slices in order to deliver an optimally conformal distribution of the desired dose mitigating beam crossing effects that occur in/between treatment slices during the initial path plan.