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US 2014/0275631 A1Published application
Process for synthesizing GGA and its derivatives
AssigneeCoyote Pharmaceuticals, Inc.
InventorsObsidiana Abril-Horpel, William Haag, Ann Pierson
Life of this patent
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Abstract
This invention relates to processes for synthesizing GGA or GGA derivatives and intermediates involved therein.
Claims8
A process for preparing a compound of formula (I):
- said process comprising:
- hydrolyzing a compound of formula (II):
- wherein:
- X and Y are each independently OR6, SR6, or X and Y together with the carbon atom they are attached to form a ring of formula:
- wherein each R6 is independently C1-C6 alkyl,
- each X1 and X2 are independently O, or S;
- q is 1 or 2;
- each X3 is independently C1-C6 alkyl;
- t is 0, 1, 2, or 3, and
- each of R1, R2, R3, R4, and R5 is independently H or C1-C6 alkyl or R1 and R2 together with the carbon atom they are joined to form a C5-C6 cycloalkyl optionally substituted with 1-3 C1-C6 alkyl.
7 more elements
A process for preparing a compound of formula (XXI):
- said process comprising:
- oxidizing a compound of formula (XXII):
- wherein:
- X and Y are each independently OR6, SR6, or X and Y together with the carbon atom they are attached to form a ring of formula:
- wherein each R6 is independently C1-C6 alkyl,
- each X1 and X2 are independently O, or S;
- q is 1 or 2;
- each X3 is independently C1-C6 alkyl;
- t is 0, 1, 2, or 3,
- each of R7 independently is H or C1-C6 alkyl;
- and
- n is 1-5,
- under suitable conditions to provide a compound of formula (XXI).
10 more elements
Dependencies are inferred from the claim text.