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US 2014/0275579 A1Published application
Novel process for the manufacture of 3-oxo-tetrahydrofuran
AssigneeBoehringer Ingelheim International GmbH
InventorsLidong XING, Weitong DONG, Jun LU, Ulrich SCHOLZ, Jun YAN, Jinsong YANG
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Abstract
This invention relates to a novel method for the preparation of 3-oxo-tetrahydrofuran comprising oxidizing 3-hydroxy-tetrahydrofuran in the presence of a catalytic amount of 2,2,6,6-tetramethyl-piperidine-N-oxyl (TEMPO) with trichloroisocyanuric acid.
Claims13
A process for preparing 3-oxo-tetrahydrofuran comprising reacting 3-hydroxy tetrahydrofuran (II)
- with 0.5-2 mol equivalents of trichloroisocyanuric acid
- in the presence of 0.001-1 mol equivalent 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) in a solvent selected from the group consisting of dichloromethane, ethyl acetate, isopropyl acetate, acetone, acetonitrile and toluene;
- and
- at a temperature of −20° C. to 40° C.
1 more element
A process for preparing 3-oxo-tetrahydrofuran comprising the following steps
- (a) conversion of butane-1,2,4 triol (III) in the presence of an acid to 3-hydroxy tetrahydrofurane (II), and
- (b) oxidation of the 3-hydroxy tetrahydrofuran from step (a) according to any of the preceding claims.
Dependencies are inferred from the claim text.