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AssigneeFUJIFILM Corporation
InventorsTaisuke FUJIMOTO, Tomohiro HASHIMOTO, Katsuyuki HAYASHI, Tomoyuki TANAKA
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Provided is a method for producing 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, including: reacting 2-aminomalonamide with a compound represented by the following formula [1] in the presence of a carboxylic acid to obtain 5-hydroxy-1H-imidazole-4-carboxamide: wherein, in formula [1], each R independently represents a C1-3 alkyl group; reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide with an acidic compound to obtain a 5-hydroxy-1H-imidazole-4-carboxamide acid salt or a hydrate thereof; and reacting the resulting 5-hydroxy-1H-imidazole-4-carboxamide acid salt or hydrate thereof with a salt in the presence of an acidic solvent to obtain the 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate.
A method for producing 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, comprising:
A method for producing 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, comprising:
A crystal of 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate having an acidic compound content of 0.1% by mass or less, wherein, in a case in which the crystal is stored in conditions of a temperature of 40° C. and a relative humidity of 75% for 2 weeks, the crystal exhibits a color difference (ΔE) of 6 or less between before the storage and after the storage.
A crystal of 5-hydroxy-1H-imidazole-4-carboxamide hydrate, wherein the crystal has diffraction peaks at diffraction angles of 8.1, 12.6, 17.1, 19.3, 20.3 and 21.6°, represented by 2θ in a powder X-ray diffraction pattern.
A pharmaceutical composition containing a crystal of 5-hydroxy-1H-imidazole-4-carboxamide hydrate, wherein the crystal has diffraction peaks at diffraction angles of 8.1, 12.6, 17.1, 19.3, 20.3 and 21.6°, represented by 2θ in a powder X-ray diffraction pattern.
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