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US 2014/0275550 A1Published application
Lansoprazole compound and novel preparation method thereof
AssigneeHainan Lingkang Pharmaceutical Co., Ltd
InventorLinggang Tao
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Abstract
A process for purifying lansoprazole comprises 1) loading crude lansoprazole material onto a macroporous resin column; 2) concentrating the eluate from the column in a crystallization vessel by vacuum; 3) seeding lansoprazole crystal; 4) crystallizing the lansoprazole; 5) separating the precipitated crystals. The process especially has large processing capacity, can be carried out continuously and therefore suitable for industrial production, improving the quality of formulated products and reducing side effects.
Claims9
A process for purifying a lansoprazole compound comprises the following steps:
- step 1) applying a crude lansoprazole material onto an adsorption resin column, which is eluted with an eluent, and collecting the eluate that containing lansoprazole;
- step 2) adding a half or more of the eluate from step 1) into a crystallization vessel, and concentrating the eluate under a negative pressure and at an elevated system temperature;
- step 3) decreasing the temperature and seeding a lansoprazole crystal;
- step 4) maintaining the mixtures at a boiling and concentrated state when fine crystal grains appear, and adding the remaining eluate from the step 1) into the crystallization vessel while stabilizing the temperature for further crystallization to obtain a precipitate;
- and optionally adjusting the temperature for better crystallization;
- step 5) separating, washing and drying the precipitate to yield a pure lansoprazole.
3 more elements
Dependencies are inferred from the claim text.