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US 2014/0275540 A1Published application
Processes For The Preparation Of An Apoptosis-Inducing Agent
AssigneeAbbVie Inc.
InventorsVincent S. Chan, Alan C. Christesen, Timothy A. Grieme, Yi-Yin Ku, Mathew M. Mulhern, Yu-Ming M. Pu
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Abstract
Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.
Claims28
A process for the preparation of a compound of formula (1):
- which comprises:
- (a) combining a compound of formula (K):
- wherein R is C1 to C12 alkyl,
- with a tert-butoxide salt, an aprotic organic solvent, and water to provide a compound of formula (L):
- and
- (b) combining the compound of formula (L) with a compound of formula (N):
- 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 4-dimethylaminopyridine, and an organic solvent to provide the compound of formula (1).
4 more elements
A process for the preparation of a compound of formula (C):
- wherein R is C1 to C12 alkyl,
- which comprises:
- (a) combining a compound of formula (A):
- with R1MgX in an aprotic organic solvent;
- wherein R1 is C1 to C6 alkyl and X is Cl, Br or I;
- (b) combining a C1 to C12 alkyl chloroformate or a di-(C1 to C12 alkyl)dicarbonate with the product of step (a), to provide the compound of formula (C).
3 more elements
A compound of the formula:
A compound of the formula:
Dependencies are inferred from the claim text.