Process for the ultrapurification of alginates
AssigneeGH Care, Inc. d/b/a Altucell, Inc.
InventorsGiuseppe Pietro Pio Basta, Riccardo Calafiore
Life of this patent
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Abstract
A method for obtaining solutions of non-structurally modified salts of alginate, with endotoxin content less than 20 EU/g includes obtaining an alginate solution having a concentration ranging from 1.6 to 2.0% by weight by adding commercial grade alginate powder to a saline solution. The alginate solution obtained is filtered on at least one hydrophilic filter, and a filtered alginate solution is recovered. The filtered alginate solution obtained is further filtered on a charge-modified hydrophobic filter, and an alginate solution having an endotoxin content less than 20 EU/g is recovered.
Claims10
A method for obtaining solutions of non-structurally modified salts of alginate, with endotoxin content less than 20 EU/g, comprising:
- a. obtaining an alginate solution having a concentration ranging from 1.6 to 2.0% by weight by adding commercial grade alginate powder to a saline solution while controlling pH;
- b. filtering the alginate solution obtained from step a) on at least one hydrophilic filter and recovering a filtered alginate solution;
- and
- c. filtering the filtered alginate solution obtained from step b) on a charge-modified hydrophobic filter and recovering an alginate solution having an endotoxin content less than 20 EU/g.
The method according to claim 5, wherein the first one of said three filters has a pharmaceutical grade 30 and a nominal pore size of 2 μm, the second one of said three filters has a pharmaceutical grade 60 and a nominal pore size of 2 μm and the third one of said three filters has a pharmaceutical grade 90 and a nominal pore size of 2 μm.
The method according to claim 7, wherein said hydrophobic filter is a Nylon 66 filter having a positive electric charge.
Dependencies are inferred from the claim text.