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AssigneesNanoimmunotech SRL, Universidad De Zaragoza, Fundación Agencia Aragonesa Para la Investigación y el Desarollo
InventorsPablo Alfonso Del Pino González de la Higuera, Jesús Martínez de la Fuente, Christian Sánchez Espinel, Ruben Santos Martínez de Laguna
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The present invention describes a method for producing multifunctional materials comprising the steps of: a) chemically activating functional groups present in a micro- or nanoparticulate base material; b) performing a nucleophilic substitution reaction between at least one terminal amino, carboxyl or thiol group of a PNA or DNA type A chain and at least one activated functional group of the base material produced in step (a); c) conjugating to a biomolecule by means of chemically activating functional groups of a PNA/DNA type B chain, which is complementary to the PNA/DNA type A chain; and d) hybridizing the PNA/DNA type A chains which are bound to the base material according to step b) and the PNA/DNA type B chains having biomolecules bound thereto according to step c) by means of PNA-PNA or PNA-DNA molecular recognition.
1-32. (canceled)
A functionalized material comprising:
A multifunctionalized material comprising:
Dependencies are inferred from the claim text.