Novel Anti-Human IL-23 Receptor Antibody
AssigneeAstellas Pharma Inc.
InventorsMakoto Ohori, Takanori Sasaki, Hiromu Sato, Katsunari Taguchi
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Abstract
[Problem] An object of the present invention is to provide an anti-human IL-23R antibody having excellent activity and/or cross-reactivity compared to conventional IL-23R antibodies, and means for using the antibody to prevent or treat various diseases in which human IL-23R is involved in pathogenesis. [Means for Solution] An anti-human IL-23R antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:5, 9, 13, 17, 21, 25 or 29 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:7, 11, 15, 19, 23, 27 or 31.
Claims24
An anti-human IL-23R antibody selected from any one of the following (1) to (7):
- (1) an anti-human IL-23R antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:5 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:7;
- (2) an anti-human IL-23R antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11;
- (3) an anti-human IL-23R antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15;
- (4) an anti-human IL-23R antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:19;
- (5) an anti-human IL-23R antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:21 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:23;
- (6) an anti-human IL-23R antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:25 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:27;
- and
- (7) an anti-human IL-23R antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:29 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:31.
Dependencies are inferred from the claim text.