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AssigneesBaxter Healthcare S.A., Baxter International Inc.
InventorsRuth Madlener, Wolfgang Teschner, Hans-Peter Schwarz, Sonja Svatos, Azra Pljevljakovic, Lena Nitsch
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The present disclosure provides, among other aspects, improved methods for the manufacture of Factor H compositions from plasma precipitation fractions. In some aspects, the methods include an improved process step for extracting Factor H from a plasma precipitate fraction with reduced co-extraction of amidolytic activities. In other aspects, the methods include a heat treatment step for reducing impurities, such as amidolytic enzymes, from a Factor H composition. In yet other aspects, the methods include improved anion exchange, heparin affinity, and/or mixed mode chromatographic enrichment of Factor H. In still other aspects, the improved methods include a combination of the individual improved process steps disclosed herein.
A method for preparing an enriched Factor H composition from plasma, the method comprising the steps:
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A method for preparing an enriched Factor H composition from plasma, the method comprising the steps:
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A method for reducing amidolytic activity in a Factor H composition, the method comprising the steps:
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A method for preparing an enriched Factor H composition from plasma, the method comprising the steps:
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A method for preparing an enriched Factor H composition from plasma, the method comprising the steps:
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A method for preparing an enriched Factor H composition from plasma, the method comprising the steps:
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Dependencies are inferred from the claim text.