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US 2014/0275478 A1Published application
Vaccines against Chlamydia sp.
AssigneeStatens Serum Institut
InventorsFrank Follmann, Ida Rosenkrands, Anja Olsen, Peter Andersen
Life of this patent
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Abstract
The present invention describes an efficient vaccine against a Chlamydia trachomatis (Ct). The vaccine is based on recombinant fusion molecules that are capable of generating a high titered neutralizing antibody response that is protective against various Ct serovars. Our invention furthermore describe the combination of these antibody promoting fragments with Ct antigens that are targets for T cells with the aim to provide a vaccine that activate both arms of the immune system.
Claims20
A polypeptide comprising
- a) an amino acid sequence comprising one or more surface exposed fragments of the same outer membrane protein expressed in a serotype of Chlamydia sp.;
- and
- b) two or more additional amino acid sequences which is either the same sequence as defined in a) or is the corresponding surface exposed fragments from a variant of said outer membrane protein expressed in a serotype of Chlamydia sp., which is different from the serotype in a).
Dependencies are inferred from the claim text.