Systems and methods employing human stem cell markers for detection, diagnosis and treatment of circulating tumor cells
OwnerWilliam Michael Schopperleinventor
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Abstract
The invention relates to systems and methods to detect circulating tumor cells in a blood sample obtained from a cancer patient. Further, this invention relates to systems and methods to determine a diagnosis or prognosis of aggressive and metastatic cancer by determining the presence and/or level of circulating tumor cells in a blood sample obtained from a cancer patient. The detection and diagnosis is based on the presence or absence of cells that express podocalyxin and/or TRA biomarkers.
Claims14
A method of detecting the presence of circulating tumor cells in a first patient, comprising:
- obtaining a first blood sample from the first patient;
- analyzing the first blood sample to determine a presence of cells that express podocalyxin and/or TRA molecules;
- determining the presence of circulating tumor cells based on the presence of cells that express podocalyxin and/or TRA molecules in the first blood sample;
- and
- determining the absence of circulating tumor cells based on the absence of cells that express podocalyxin and/or TRA molecules in the first blood sample.
A system for detecting circulating tumor cells in a patient, comprising:
- a tool for obtaining a blood sample from the patient;
- a detector means for determining a presence or an absence of cells that express podocalyxin and/or TRA molecules in the blood sample;
- and
- an indicator means to display the presence of circulating tumor cells based on the presence of cells that express podocalyxin and/or TRA molecules in the sample or to display the absence of circulating tumor cells based on the absence of cells that express podocalyxin and/or TRA molecules in the sample.
A method of detecting and diagnosing circulating tumor cells in a patient, comprising:
- obtaining a blood sample from the patient;
- analyzing the blood sample for a presence of cells that express podocalyxin and/or TRA molecules;
- determining the presence or an absence of the cells that express podocalyxin and/or TRA molecules in the blood sample;
- providing a diagnosis of the presence of circulating tumor cells in the patient based on the presence of cells that express podocalyxin and/or TRA molecules in the blood sample;
- and
- providing a diagnosis of the absence of circulating tumor cells in the patient based on the absence of cells that express podocalyxin and/or TRA molecules in the blood sample.
Dependencies are inferred from the claim text.