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US 2014/0275274 A1Published application
Synergistic ophthalmic compositions for disinfecting contact lenses
AssigneeAbbott Medical Optics Inc.
InventorsStanley W. Huth, Denise Tran
Life of this patent
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Abstract
Compositions and methods for disinfecting contact lenses using the compositions are disclosed. The compositions include a combination of alexidine and chlorhexidine, which surprisingly causes the composition to exhibit synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by at least 1.2 log.
Claims21
An ophthalmic composition comprising:
- from about 0.7 ppm to about 1.3 ppm alexidine;
- and
- from about 1 ppm to about 5 ppm chlorhexidine,
- wherein the composition exhibits synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by at least 1.2 log.
1 more element
An ophthalmic composition comprising:
- from about 0.7 ppm to about 1.15 ppm alexidine;
- from about 1.5 ppm to about 2.75 ppm chlorhexidine;
- from about 0.5 ppm to about 3.3 ppm poly[(dimethyliminio)-2-butene-1,4-diyl chloride], α-[4-[tris(2-hydroxyethyl) ammonio]-2-butenyl]-Ω-[tris(2-hydroxyethyl)ammonio]-dichloride;
- and
- from about 0.05% to about 0.15% by weight per volume ethylenediaminetetraacetic acid (EDTA),
- wherein alexidine and chlorhexidine together exhibit synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by 1.2 to 4.3 log.
3 more elements
An ophthalmic composition comprising:
- from about 0.5 ppm to about 1.15 ppm alexidine;
- from about 1 ppm to about 5.5 ppm chlorhexidine;
- from about 0.5 ppm to about 3.3 ppm poly[(dimethyliminio)-2-butene-1,4-diyl chloride], α-[4-[tris(2-hydroxyethyl) ammonio]-2-butenyl]-Ω-[tris(2-hydroxyethyl)ammonio]-dichloride;
- from about 0.04 to about 0.15% by weight per volume of ethylenediaminetetraacetic acid (EDTA);
- from about 0.18 to about 0.70% by weight per volume of sodium chloride;
- from about 0.50 to about 0.66% by weight per volume of boric acid;
- from about 0.15 to about 0.30% by weight per volume of sodium borate;
- from about 0.22 to about 0.80% by weight per volume of sodium citrate;
- from about 0.03 to about 0.15% by weight per volume of a surfactant;
- and
- from about 0.03 to about 0.25% by weight per volume of a viscosity-inducing component,
- wherein alexidine and chlorhexidine together exhibit synergistic antimicrobial activity against Candida albicans by reducing a concentration of Candida albicans by 1.2 to 4.0 log.
9 more elements
A method of disinfecting a contact lens comprising:
- contacting the contact lens with a disinfecting solution, the disinfecting solution including from about 0.7 ppm to about 1.3 ppm alexidine, from about 1 ppm to about 5 ppm chlorhexidine, and from about 0.5 ppm to about 5 ppm poly[(dimethyliminio)-2-butene-1,4-diyl chloride], α-[4-[tris(2-hydroxyethyl) ammonio]-2-butenyl]-Ω-[tris(2-hydroxyethyl)ammonio]-dichloride;
- and
- removing the contact lens from the disinfecting solution, wherein synergistic antimicrobial activity against Candida albicans has been exhibited and a concentration of Candida albicans has been reduced by at least 1.2 log.
Dependencies are inferred from the claim text.