Composition of 5-Nitrobenzoate Derivatives as Anti-Metastatic Agent that Inhibits Tumor Cell-Induced Platelet Aggregation
AssigneeChang Gung University
InventorsChing-Ping TSENG, Pei-Wen HSIEH, Yao-Wen CHANG
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Abstract
Disclosed are 5-nitrobenzoate derivatives of Formula I, and the preparation method therefor, wherein R is referred to hydrogen (H), unsubstituted, mono-substituted, di-substituted or tri-substituted benzoyl moiety. 5-Nitrobenzoare derivatives of Formula I do not affect the platelet aggregation, possesses the inhibitory activity related to the tumor cell-induced platelet aggregation (TCIPA), and further specifically inhibits podoplanin-induced platelet aggregation. Therefore, 5-nitrobenzoates of the invention are applicable in its therapeutic use as the novel therapeutic agent in preventing tumor metastasis.
Claims8
(canceled)
(canceled)
A method for blocking an interaction between a C-type lectin-like receptor 2 and a podoplanin or blocking an effect caused by the interaction therebetween, by comprising step of using a 5-nitrobenzoate derivative as represented by formula I,
- wherein R is one selected from a group consisting of a hydrogen, anunsubstituted benzoyl moiety
- a mono-substituted benzoyl moiety a
- di-substituted benzoyl moiety
- and a tri-substituted benzoyl moiety
- and each of R1, R2, R3, R4, R5 and R6 is one selected from a group consisting of a fluoride, a chloride, a bromide, an iodide and a methyl group.
A method for blocking a pathway of a tumor cell-induced platelet aggregation, comprising a step of using a 5-nitrobenzoate derivative as represented by formula I,
- wherein R is one selected from a group consisting of a hydrogen, an unsubstituted benzoyl moiety
- a mono-substituted benzoyl moiety
- a di-substituted benzoyl moiety
- and a tri-substituted benzoyl moiety
- and each of R1, R2, R3, R4, R5 and R6 is one selected from a group consisting of a fluoride, a chloride, a bromide, an iodide and a methyl group.
A 5-nitrobenzoate derivative represented by formula I,
- wherein R is one selected from a group consisting of a hydrogen, an unsubstituted benzoyl moiety
- a mono-substituted benzoyl moiety
- a di-substituted benzoyl moiety
- and a tri-substituted benzoyl moiety
- each of R1, R2, R3, R4, R5 and R6 is one selected from a group consisting of a fluoride, a chloride, a bromide, an iodide and a methyl group.
A method for preparing a 5-nitrobenzoate derivative as represented by formula I,
- the method comprising a step of using an N-(2-aminoethyl)-2-hydroxy-5-nitrobenzamide as one of a starting material and an intermediate, wherein R is one selected from a group consisting of a hydrogen, an unsubstituted benzoyl moiety
- a mono-substituted benzoyl moiety
- a di-substituted benzoyl moiety
- and a tri-substituted benzoyl moiety
- and each of R1, R2, R3, R4, R5 and R6 is one selected from a group consisting of a fluoride, a chloride, a bromide, an iodide and a methyl group.
Dependencies are inferred from the claim text.