Phenyl carbamate compounds for use in preventing or treating pediatric epilesy and epilesy-related syndromes
AssigneeBio-Pharm Solutions Co., Ltd.
InventorYONG MOON CHOI
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Abstract
The present invention provides a pharmaceutical composition for preventing and/or treating a pediatric epilepsy or epilepsy-related syndrome comprising the phenyl carbamate compound as an active ingredient, and a use of the phenyl carbamate compound for preventing and/or treating pediatric epilepsy or pediatric epilepsy-related syndromes.
Claims14
A pharmaceutical composition for preventing or treating a pediatric epilepsy or a pediatric epilepsy-related syndrome comprising a phenyl carbamate compound represented by Chemical Formula I or a pharmaceutically acceptable salt thereof, as an active ingredient:
- wherein,
- X is a halogen,
- n, that means the number of substituent X, is an integer from 1 to 5,
- R1 is a linear or branched alkyl group of C1-C4,
- A is hydrogen or a carbamoyl group represented by
- B is hydrogen, a carbamoyl group represented by
- trialkyl silyl groups, trialkylaryl silyl groups (wherein the total number of alkyl and aryl groups is three), or a trialkyl silyl ether group, wherein each alkyl group is independently selected from the group consisting of linear, branched, or cyclic C1-C4 alkyl groups, and each aryl group is independently selected from the group consisting of C5-C8 aryl groups,
- A and B are not carbamoyl derivatives at same time, and
- R2 and R3 may be the same as or different from each other, and independently selected from the group consisting of hydrogen, a linear or branched alkyl group of C1-C4, a cycloalkyl group of C3-C8, and benzyl group.
A method of preventing or treating epilepsy or epilepsy-related syndrome in a pediatric subject, comprising administering a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof, to a pediatric subject in need of treatment:
- wherein,
- X is a halogen,
- n, that means the number of substituent X, is an integer from 1 to 5,
- R1 is a linear or branched alkyl group of C1-C4,
- A is hydrogen or a carbamoyl group represented by
- B is hydrogen, a carbamoyl group represented by
- trialkyl silyl groups, trialkylaryl silyl groups (wherein the total number of alkyl and aryl groups is three), or a trialkyl silyl ether group, wherein each alkyl group is independently selected from the group consisting of linear, branched, or cyclic C1-C4 alkyl groups, and each aryl group is independently selected from the group consisting of C5-C8 aryl groups,
- A and B are not carbamoyl derivatives at same time, and
- R2 and R3 may be the same as or different from each other, and independently selected from the group consisting of hydrogen, a linear or branched alkyl group of C1-C4, a cycloalkyl group of C3-C8, and benzyl group.
Dependencies are inferred from the claim text.