Methods for treating denervation-induced muscle atrophy
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsHuibin Tang, Joseph Shrager
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Abstract
The present invention provides methods for the treatment of denervation-induced skeletal muscle atrophy, and generally, denervation-induced skeletal muscle degeneration diseases using agents that decrease the activity of mammalian target of rapamycin and/or the activity of at least one of the Forkhead Box Transcription Factors 1, 3 and 4.
Claims40
A method of attenuating skeletal muscle atrophy in a mammalian subject, comprising administering to said subject suffering from denervation-induced skeletal muscle atrophy a composition comprising an agent that decreases activity of mammalian target of rapamycin in a dosage and dosing regimen effective to attenuate denervation-induced skeletal muscle atrophy.
A method of preventing skeletal muscle atrophy in a mammalian subject, comprising administering to said subject being at risk of developing a denervation-induced skeletal muscle atrophy a composition comprising an agent that decreases activity of mammalian target of rapamycin in a dosage and dosing regimen effective to prevent denervation-induced skeletal muscle atrophy.
A method of attenuating skeletal muscle atrophy in a mammalian subject, comprising administering to said subject suffering from denervation-induced skeletal muscle atrophy a composition comprising an agent that decreases activity of at least one of Forkhead Box Transcription Factors 1, 3 and 4 in a dosage and dosing regimen effective to attenuate denervation-induced skeletal muscle atrophy.
A method of preventing skeletal muscle atrophy in a mammalian subject, comprising administering to said subject being at risk of developing a denervation-induced skeletal muscle atrophy a composition comprising an agent that decreases activity of at least one of Forkhead Box Transcription Factors 1, 3 and 4 in a dosage and dosing regimen effective to prevent skeletal muscle atrophy.
Dependencies are inferred from the claim text.