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US 2014/0275227 A1Published application
Compositions and methods of altering cholesterol levels
AssigneeModerna Therapeutics, Inc.
InventorsStephen G. Hoge, Antonin de Fougerolles, Jeff Lynn Ellsworth
Life of this patent
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Abstract
The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmRNA molecules.
Claims4
A modified mRNA encoding a LDLR mutant, said modified mRNA comprising at least one nucleoside modification, wherein said at least one nucleoside modification is 1-methylpseudouridine and wherein the encoded LDLR mutant comprises at least one amino acid mutation in a region comprising amino acids 316-339 of SEQ ID NO:
- 19.
Dependencies are inferred from the claim text.