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US 2014/0275223 A1Published application
MicroRNA-BASED APPROACH TO TREATING MALIGNANT PLEURAL MESOTHELIOMA
AssigneeAsbestos Diseases Research Institute
InventorsGlen Reid, Nico van Zandwijk
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Abstract
The invention relates to microRNA mimics, corresponding to the miR-15/107 family, and to methodology for using microRNA mimics to treat malignant pleural mesothelioma (MPM) by restoring regulation of the expression of target genes of the miR-15/107 family in MPM tumor cells.
Claims8
A double-stranded microRNA mimic for the treatment of malignant pleural mesothelioma (MPM), wherein the microRNA mimic comprises:
- (a) a mature sequence corresponding to a miR-15/107 family member;
- and
- (b) a passenger strand,
- wherein the mature sequence contains AGCAGC at positions 2-7 or 1-6 at the 5′ end.
1 more element
Dependencies are inferred from the claim text.